By Alice Melao
Via Cerebral Palsy News Today
Transplanting stem cells from bone marrow to the spinal canal, where they can reach the cerebrospinal fluid, improves cerebral palsy patients’ movement, a Phase 2 clinical trial indicates.
The study, “Outcomes of autologous bone marrow mononuclear cells for cerebral palsy: an open label uncontrolled clinical trial,” was published in the journal BMC Pediatrics.
Stem cells can morph into other cells, including neurological cells such as neurons and astrocytes. They also can deliver beneficial signaling molecules to injured sites, promoting repair.
These findings suggest that stem cells could be used to help the body recover from several diseases. In fact, a stem cell collected from bone marrow, known as a bone marrow mononuclear cell, or BMMNC, may be able to help cerebral palsy patients recover motor function, previous research indicates.
Cerebral palsy is caused by damage to, or abnormalities inside, the developing brain. These problems disrupt the brain’s ability to control movement and maintain posture and balance.
The recent Phase 2 clinical trial (NCT02569775) evaluated the safety and effectiveness of transplanting BMMNCs to the spinal canal. From the canal the stem canals can reach the cerebrospinal fluid, which acts as a cushion to protect the brain.
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